Wegovy Pill Oral Weight Loss Tablet
(Oral Semaglutide)

The Wegovy pill is a prescription-only weight management medication, taken once a day as a tablet rather than a weekly injection. It contains semaglutide, the same active ingredient found in Wegovy injections, but reaches your bloodstream through your digestive system instead of under the skin.

To make this possible, the tablet uses SNAC technology, a coating that protects the semaglutide from being broken down by stomach acid before it can be absorbed. Because a smaller proportion of the dose is absorbed this way compared with an injection, the maintenance dose is higher (25mg daily) to achieve a comparable effect to the 2.4mg weekly injection.

The Wegovy pill mimics GLP-1, a natural hormone your gut releases after eating. It works by:

• Reducing appetite: signalling to your brain that you're full, so you feel satisfied with smaller portions and experience fewer cravings between meals

• Slowing digestion: keeping food in your stomach for longer, which prolongs feelings of fullness

• Supporting blood sugar regulation: helping to reduce the energy dips and hunger spikes that can follow a meal

It's designed to be used alongside a reduced-calorie diet and increased physical activity, not as a standalone fix.

Both contain semaglutide and work in the same way, but there are some practical differences:

• How you take it: a daily tablet rather than a weekly injection, no needles involved

• Frequency: once a day compared with once a week

• Storage: tablets are kept at room temperature; injections need refrigeration

• Absorption: the tablet must be taken on an empty stomach with specific timing, since food and other liquids reduce how much is absorbed. The injection is absorbed more predictably under the skin

Some people prefer the routine of a daily tablet, others prefer the injection. Your clinician can help you weigh this up based on your history and preferences.

Yes, but always under clinical supervision rather than doing this yourself. If you're switching from Wegovy injections, you'd typically take your final injection as scheduled and wait 7 days before starting the tablet. If you're switching from Mounjaro, a similar break is usually recommended. Your prescriber will confirm your starting dose based on your treatment history, current dose, and how you've tolerated treatment so far, dose-equivalence guides are a starting point, not a substitute for clinical review.

Everyone starts on the lowest dose, 1.5mg once daily. From there, the dose typically increases every 30 days:

• Days 1–30: 1.5mg once daily

• Days 31–60: 4mg once daily

• Days 61–90: 9mg once daily

• Day 91 onwards: 25mg once daily (maintenance dose)

Your clinician reviews your progress at each step to confirm the right next dose for you. Some people stay on a lower dose for longer, which is completely fine. The goal is steady, sustainable progress with manageable side effects, not rushing to the top dose.

No. Only one GLP-1 medication should be taken at a time, unless a healthcare professional has specifically advised otherwise. Combining the oral pill with an injectable Wegovy or another GLP-1 treatment increases the risk of side effects. Always tell your prescriber about any other weight loss medications you're taking or have recently stopped.

Most people notice a change in appetite within the first 1–4 weeks. Measurable weight loss tends to become apparent from around week 5–6 onwards, as your dose increases through the escalation schedule.

In the OASIS 1 trial, participants taking the Wegovy pill lost an average of 15.1% of their body weight over 68 weeks, compared with 2.4% in the placebo group. In the OASIS 4 trial, those on the 25mg maintenance dose for 64 weeks lost an average of 16.6% of their body weight, with around one in three achieving 20% or more. Results depend on consistent daily use, taking the tablet correctly, and maintaining lifestyle changes alongside treatment.

Oral semaglutide has a safety profile consistent with the wider GLP-1 class of medications. It's only prescribed after a full medical assessment, and your treatment is monitored by our clinical team throughout.

Side effects are usually more noticeable when you start treatment or step up a dose, and tend to ease as your body adjusts.

Very common: nausea, vomiting, diarrhoea, constipation, stomach pain, headaches, and fatigue. Mild stomach symptoms and headaches can often be managed with over-the-counter remedies; for nausea, try fresh air, cold drinks, and smaller, more frequent meals.

Less common (affecting fewer than 1 in 100 people): faster heart rate, low blood sugar, kidney stones, and pancreatitis.

Rare (fewer than 1 in 1,000 people): serious allergic reaction (anaphylaxis) and angioedema, a type of swelling beneath the skin that can affect the face, lips, tongue, or throat.

Seek immediate medical attention if you experience difficulty breathing, swelling, or severe stomach pain. If anything doesn't go away or gets worse, get in touch with our clinical team or your GP.

Yes. You'll need to complete a short online consultation so one of our clinicians can assess your suitability before a prescription is issued. It's a prescription-only medication, so it can't be bought over the counter.

At room temperature, between 20°C and 25°C, in a dry place. Keep the tablets in their original child-resistant bottle with the cap tightly closed, and out of reach of children.

You shouldn't take it if you have a personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2, a previous serious allergic reaction to semaglutide, or if you're pregnant, trying to conceive, or breastfeeding. Always share your full medical history and current medications with your prescriber before starting.